A new species of Cetopsorhamdia is described from material collected on rapid inventories and ichthyological expeditions in the Amazon region of Peru, Ecuador and Colombia. The new species can be differentiated from all other species of Cetopsorhamdia by the colouration pattern on fins, number of vertebrae, number of ribs, level insertion of dorsal fin, number of rays on dorsal and pectoral fin, osteological characters and several other morphometric characters. The new species is distributed along tributaries of the upper Amazon River basin in Peru, Colombia and Ecuador.